| Title | A high signal-to-noise ratio and high-frequency seesaw cantilever for high-speed atomic force microscopy. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Li L, Miyagi A, Scheuring S |
| Journal | Nat Commun |
| Volume | 16 |
| Issue | 1 |
| Pagination | 10307 |
| Date Published | 2025 Nov 21 |
| ISSN | 2041-1723 |
| Abstract | The cantilever mediates tip-sample interaction detection in all atomic force microscopes (AFMs). Canonical cantilevers are beams, where length, width, and thickness define the physical properties such as stiffness and resonant frequency, that also mediate laser-reflection to report on cantilever deflection. High-speed AFM (HS-AFM) demands miniaturized cantilevers that are soft and fast, but miniaturized beams reduce laser signal quality. Here, we present a seesaw cantilever with a rigid reflective board oscillating over torsional hinges separating the laser-reflective and mechanical functions. Finite element analysis verified the seesaw mechanism. The board can be optimized for laser-reflection and the shortened distance between tip and hinges enhances the angular sensitivity, while the stiffness is tunable via the hinge dimensions. We detail seesaw cantilever design, fabrication, tip addition, physical equations, and sub-molecular imaging of biological samples. We propose that seesaw cantilevers offer a promising alternative to traditional beam cantilevers for diverse AFM applications. |
| DOI | 10.1038/s41467-025-65240-x |
| Alternate Journal | Nat Commun |
| PubMed ID | 41271756 |
| PubMed Central ID | PMC12639161 |
| Grant List | R01 NS110790 / NS / NINDS NIH HHS / United States R01 NS134559 / NS / NINDS NIH HHS / United States R01NS110790 / / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) / R01NS134559 / / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) / |
