Department of Anesthesiology

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Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization.

TitleDopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization.
Publication TypeJournal Article
Year of Publication1991
AuthorsMeister B, Schultzberg M, Hemmings HC, Greengard P, Goldstein M, Hökfelt T
JournalJ Auton Nerv Syst
Volume36
Issue1
Pagination75-84
Date Published1991 Oct
ISSN0165-1838
KeywordsAdrenal Glands, Animals, Cyclic AMP, Dopamine, Dopamine and cAMP-Regulated Phosphoprotein 32, Guinea Pigs, Humans, Immunohistochemistry, Molecular Weight, Nerve Tissue Proteins, Phosphoproteins, Primates, Rabbits, Staining and Labeling, Tissue Distribution
Abstract

The cellular localization of a dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of an apparent molecular weight of 32,000 (DARPP-32) was investigated in mouse, rat, rabbit, guinea pig, cat, monkey (Macaca fascicularis and Marmoset) and human adrenal gland by means of indirect immunofluorescence histochemistry. DARPP-32-like immunoreactivity (-LI) was demonstrated in chromaffin cells in the adrenal medulla of rabbit, guinea-pig, cat, monkey and human, but not in mouse or rat. In the Marmoset monkey, DARPP-32-LI was also observed in the zona glomerulosa of the adrenal cortex. It has been shown that dopamine and dopaminergic agonists inhibit catecholamine release from chromaffin cells and aldosterone secretion from cells in the adrenal cortex. The present results suggest that DARPP-32, an intracellular third messenger for dopamine, may be part of the signal transduction mechanism for dopamine acting on the adrenal gland.

Alternate JournalJ. Auton. Nerv. Syst.
PubMed ID1721636
Grant ListMH 40899 / MH / NIMH NIH HHS / United States
MH43230 / MH / NIMH NIH HHS / United States