Department of Anesthesiology

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Characterization of the Rapid Drop in Pulse Oximetry Reading After Intraoperative Administration of Methylene Blue in Open Thoracoabdominal Aortic Repairs.

TitleCharacterization of the Rapid Drop in Pulse Oximetry Reading After Intraoperative Administration of Methylene Blue in Open Thoracoabdominal Aortic Repairs.
Publication TypeJournal Article
Year of Publication2019
AuthorsRong LQ, Mauer E, Mustapich TL, White RS, Di Franco A, Girardi LN, Gaudino M, Pryor KO
JournalAnesth Analg
Date Published2019 Aug 06
ISSN1526-7598
Abstract

This study evaluates the changes of oxygen saturation (SpO2) after intravenous administration of methylene blue in 103 patients undergoing open repair of thoracoabdominal aortic aneurysms. We found that SpO2 decreased by a median (interquartile range [IQR]) of 49% (37%-81%) <1 minute after methylene blue administration and recovered completely after approximately 6 minutes-median (IQR) of 270 seconds (180-510). A shorter time to nadir SpO2 was associated with a higher nadir (Spearman r [95% confidence interval {CI}], -0.32 [-0.50 to -0.13]; P = .001). Body surface area (BSA) was positively correlated with nadir SpO2 (Spearman r [95% CI], 0.36 [0.15-0.51]; P < .001).

DOI10.1213/ANE.0000000000004325
Alternate JournalAnesth. Analg.
PubMed ID31397700