Department of Anesthesiology

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Calbindin controls release probability in ventral tegmental area dopamine neurons.

TitleCalbindin controls release probability in ventral tegmental area dopamine neurons.
Publication TypeJournal Article
Year of Publication2012
AuthorsPan P-Y, Ryan TA
JournalNat Neurosci
Volume15
Issue6
Pagination813-5
Date Published2012 Jun
ISSN1546-1726
KeywordsAnimals, Calcium-Binding Protein, Vitamin D-Dependent, Dopamine, Dopaminergic Neurons, Exocytosis, Immunohistochemistry, Rats, Rats, Sprague-Dawley, Transfection, Ventral Tegmental Area
Abstract

Relatively little is known about the molecular control of midbrain dopamine release. Using high-fidelity imaging of pHluorin-tagged vesicular monoamine transporter 2 in dopamine neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses. In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.

DOI10.1038/nn.3099
Alternate JournalNat. Neurosci.
PubMed ID22544312
PubMed Central IDPMC3703651
Grant ListDA0101540 / DA / NIDA NIH HHS / United States
MH085783 / MH / NIMH NIH HHS / United States
R01 MH085783 / MH / NIMH NIH HHS / United States