| Title | Calbindin controls release probability in ventral tegmental area dopamine neurons. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Pan P-Y, Ryan TA |
| Journal | Nat Neurosci |
| Volume | 15 |
| Issue | 6 |
| Pagination | 813-5 |
| Date Published | 2012 Jun |
| ISSN | 1546-1726 |
| Keywords | Animals, Calcium-Binding Protein, Vitamin D-Dependent, Dopamine, Dopaminergic Neurons, Exocytosis, Immunohistochemistry, Rats, Rats, Sprague-Dawley, Transfection, Ventral Tegmental Area |
| Abstract | Relatively little is known about the molecular control of midbrain dopamine release. Using high-fidelity imaging of pHluorin-tagged vesicular monoamine transporter 2 in dopamine neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses. In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons. |
| DOI | 10.1038/nn.3099 |
| Alternate Journal | Nat. Neurosci. |
| PubMed ID | 22544312 |
| PubMed Central ID | PMC3703651 |
| Grant List | DA0101540 / DA / NIDA NIH HHS / United States MH085783 / MH / NIMH NIH HHS / United States R01 MH085783 / MH / NIMH NIH HHS / United States |