Department of Anesthesiology

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Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

TitleAnaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.
Publication TypeJournal Article
Year of Publication2013
AuthorsJevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC
JournalBr J Anaesth
Volume111
Issue2
Pagination143-51
Date Published2013 Aug
ISSN1471-6771
KeywordsAged, Aged, 80 and over, Anesthesia, General, Anesthetics, General, Animals, Austria, Brain, Cognition Disorders, Great Britain, Humans, Infant, Neuronal Plasticity, Neurotoxicity Syndromes, Periodicals as Topic
Abstract

Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both extremes of age. A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anaesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. A group of experts in anaesthetic neuropharmacology and neurotoxicity convened in Salzburg, Austria for the BJA Salzburg Seminar on Anaesthetic Neurotoxicity and Neuroplasticity. This focused workshop was sponsored by the British Journal of Anaesthesia to review and critically assess currently available evidence from animal and human studies, and to consider the direction of future research. It was concluded that mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes. However, definitive clinical data remain elusive. Since general anaesthesia often cannot be avoided regardless of patient age, it is important to understand the complex mechanisms and effects involved in anaesthesia-induced neurotoxicity, and to develop strategies for avoiding or limiting potential brain injury through evidence-based approaches.

DOI10.1093/bja/aet177
Alternate JournalBr J Anaesth
PubMed ID23722106
PubMed Central IDPMC3711392
Grant List2P01 1HD16596-26 / HD / NICHD NIH HHS / United States
GM49831 / GM / NIGMS NIH HHS / United States
GM58055 / GM / NIGMS NIH HHS / United States
HD 44517 / HD / NICHD NIH HHS / United States
HD 44517S / HD / NICHD NIH HHS / United States
K08 GM077057 / GM / NIGMS NIH HHS / United States
MOP-106423 / / Canadian Institutes of Health Research / Canada
NS053898 / NS / NINDS NIH HHS / United States
NS56315 / NS / NINDS NIH HHS / United States
PCN-102993 / / Canadian Institutes of Health Research / Canada
R01 AG041274 / AG / NIA NIH HHS / United States
R01 GM058055 / GM / NIGMS NIH HHS / United States
R01 GM088801 / GM / NIGMS NIH HHS / United States
R01 GM088817 / GM / NIGMS NIH HHS / United States
R01 HD044517 / HD / NICHD NIH HHS / United States
R21AG038994 / AG / NIA NIH HHS / United States
TW007423-128322 / TW / FIC NIH HHS / United States
/ / Medical Research Council / United Kingdom