Department of Anesthesiology

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Publications

Author Title [ Type(Asc)] Year
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Journal Article
Kim DM, Nimigean CM.  2016.  Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.. Cold Spring Harb Perspect Biol. 8(5)
Posson DJ, McCoy JG, Nimigean CM.  2013.  The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.. Nat Struct Mol Biol. 20(2):159-66.
Chiu P-L, Pagel MD, Evans J, Chou H-T, Zeng X, Gipson B, Stahlberg H, Nimigean CM.  2007.  The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution.. Structure. 15(9):1053-64.
McCoy JG, Nimigean CM.  2012.  Structural correlates of selectivity and inactivation in potassium channels.. Biochim Biophys Acta. 1818(2):272-85.
Tanabe M, Nimigean CM, Iverson TM.  2010.  Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.. Proc Natl Acad Sci U S A. 107(15):6811-6.
Posson DJ, Rusinova R, Andersen OS, Nimigean CM.  2018.  Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.. Methods Mol Biol. 1684:223-235.
Qian X, Nimigean CM, Niu X, Moss BL, Magleby KL.  2002.  Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels.. J Gen Physiol. 120(6):829-43.
Rusinova R, Kim DM, Nimigean CM, Andersen OS.  2014.  Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay.. Biophys J. 106(5):1070-8.
Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S.  2016.  Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.. Nat Commun. 7:12789.
Nimigean CM.  2006.  A radioactive uptake assay to measure ion transport across ion channel-containing liposomes.. Nat Protoc. 1(3):1207-12.
Nimigean CM, Allen TW.  2011.  Origins of ion selectivity in potassium channels from the perspective of channel block.. J Gen Physiol. 137(5):405-13.
Banerjee S, Nimigean CM.  2011.  Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers.. J Gen Physiol. 137(2):217-23.
Nimigean CM, Miller C.  2002.  Na+ block and permeation in a K+ channel of known structure.. J Gen Physiol. 120(3):323-35.
Thompson AN, Posson DJ, Parsa PV, Nimigean CM.  2008.  Molecular mechanism of pH sensing in KcsA potassium channels.. Proc Natl Acad Sci U S A. 105(19):6900-5.
Posson DJ, Thompson AN, McCoy JG, Nimigean CM.  2013.  Molecular interactions involved in proton-dependent gating in KcsA potassium channels.. J Gen Physiol. 142(6):613-24.
Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM.  2009.  Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.
Cheng WWL, McCoy JG, Thompson AN, Nichols CG, Nimigean CM.  2011.  Mechanism for selectivity-inactivation coupling in KcsA potassium channels.. Proc Natl Acad Sci U S A. 108(13):5272-7.
Kowal J, Chami M, Baumgartner P, Arheit M, Chiu P-L, Rangl M, Scheuring S, Schröder GF, Nimigean CM, Stahlberg H.  2014.  Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.. Nat Commun. 5:3106.
Rheinberger J, Gao X, Schmidpeter PAm, Nimigean CM.  2018.  Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.. Elife. 7
Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM.  2018.  Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.. J Gen Physiol.
Nimigean CM, Pagel MD.  2007.  Ligand binding and activation in a prokaryotic cyclic nucleotide-modulated channel.. J Mol Biol. 371(5):1325-37.
McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Cartagena AJaramillo, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS et al..  2014.  A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.. J Biol Chem. 289(14):9535-46.
Xu Y, Zhang D, Rogawski R, Nimigean CM, McDermott AE.  2019.  Identifying coupled clusters of allostery participants through chemical shift perturbations.. Proc Natl Acad Sci U S A. 116(6):2078-2085.
Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J.  2017.  Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6
Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.  2018.  High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.. Structure. 26(1):20-27.e3.