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Department of Anesthesiology Bookshelf
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Savarese, John J
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C
Heerdt PM
,
Kang R
,
The' A
,
Hashim M
,
Mook RJ
,
Savarese JJ
. 2004.
Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs.
.
Anesthesiology. 100(4):846-51.
PubMed
Google Scholar
Belmont MR
,
Lien CA
,
Tjan J
,
Bradley E
,
Stein B
,
Patel SS
,
Savarese JJ
. 2004.
Clinical pharmacology of GW280430A in humans.
.
Anesthesiology. 100(4):768-73.
PubMed
Google Scholar
Sunaga H
,
Malhotra JK
,
Yoon E
,
Savarese JJ
,
Heerdt PM
. 2010.
Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.
.
Anesthesiology. 112(4):900-9.
PubMed
Google Scholar
D
Heerdt PM
,
Sunaga H
,
Owen JS
,
Murrell MT
,
Malhotra JK
,
Godfrey D
,
Steinkamp M
,
Savard P
,
Savarese JJ
,
Lien CA
. 2016.
Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man.
.
Anesthesiology. 125(6):1136-1143.
PubMed
Google Scholar
E
Suzuki T
,
Lien CA
,
Belmont MR
,
Tjan J
,
Savarese JJ
. 2003.
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.
.
Can J Anaesth. 50(9):879-85.
PubMed
Google Scholar
F
Lien CA
,
Savard P
,
Belmont M
,
Sunaga H
,
Savarese JJ
. 2009.
Fumarates: unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine.
.
J Crit Care. 24(1):50-7.
PubMed
Google Scholar
G
Sunaga H
,
Zhang Y
,
Savarese JJ
,
Emala CW
. 2010.
Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs.
.
Anesthesiology. 112(4):892-9.
PubMed
Google Scholar
N
Boros EE
,
Samano V
,
Ray JA
,
Thompson JB
,
Jung DK
,
Kaldor I
,
Koble CS
,
Martin MT
,
Styles VL
,
Mook RA
et al.
. 2003.
Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.
.
J Med Chem. 46(12):2502-15.
PubMed
Google Scholar
Heerdt PM
,
Wagner CL
,
DeMais M
,
Savarese JJ
. 2011.
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles.
.
J Pharmacol Toxicol Methods. 64(2):111-8.
PubMed
Google Scholar
Heerdt PM
,
Sunaga H
,
Savarese JJ
. 2015.
Novel neuromuscular blocking drugs and antagonists.
.
Curr Opin Anaesthesiol. 28(4):403-10.
PubMed
Google Scholar
P
Heerdt PM
,
Malhotra JK
,
Pan BY
,
Sunaga H
,
Savarese JJ
. 2010.
Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs.
.
Anesthesiology. 112(4):910-6.
PubMed
Google Scholar
Kaullen JD
,
Owen JS
,
Brouwer KLR
,
Heerdt PM
,
Lien CA
,
Savarese JJ
,
Schmith VD
. 2018.
Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers.
.
Anesthesiology. 128(6):1107-1116.
PubMed
Google Scholar
Savarese JJ
,
Sunaga H
,
McGilvra JD
,
Belmont MR
,
Murrell MT
,
Jeannotte E
,
Cooke FE
,
Wastila WB
,
Heerdt PM
. 2018.
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine.
.
Anesthesiology. 129(5):970-988.
PubMed
Google Scholar
Sunaga H
,
Savarese JJ
,
McGilvra JD
,
Heerdt PM
,
Belmont MR
,
Van Ornum SG
,
Murrell MT
,
Malhotra JK
,
Savard PM
,
Jeannotte E
et al.
. 2016.
Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat.
.
Anesthesiology. 125(4):732-743.
PubMed
Google Scholar
Savarese JJ
,
Belmont MR
,
Hashim MA
,
Mook RA
,
Boros EE
,
Samano V
,
Patel SS
,
Feldman PL
,
Schultz J-AI
,
McNulty M
et al.
. 2004.
Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.
.
Anesthesiology. 100(4):835-45.
PubMed
Google Scholar
R
Savarese JJ
,
McGilvra JD
,
Sunaga H
,
Belmont MR
,
Van Ornum SG
,
Savard PM
,
Heerdt PM
. 2010.
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.
.
Anesthesiology. 113(1):58-73.
PubMed
Google Scholar