Department of Anesthesiology
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Journal Article
Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL.  2008.  Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.. J Neurosci. 28(1):106-15.
Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG et al..  2008.  Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).. FASEB J. 22(10):3648-60.
Ying S-W, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA.  2012.  Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.. PLoS One. 7(8):e42756.
Ying S-W, Goldstein PA.  2005.  Propofol-block of SK channels in reticular thalamic neurons enhances GABAergic inhibition in relay neurons.. J Neurophysiol. 93(4):1935-48.
Ying S-W, Goldstein PA.  2005.  Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.. Mol Pain. 1:2.
Ying S-W, Abbas SY, Harrison NL, Goldstein PA.  2006.  Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.. Eur J Neurosci. 23(2):465-80.
Goldstein PA, Elsen FP, Ying S-W, Ferguson C, Homanics GE, Harrison NL.  2002.  Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit.. J Neurophysiol. 88(6):3208-17.
Ying S-W, Tibbs GR, Picollo A, Abbas SY, R Sanford L, Accardi A, Hofmann F, Ludwig A, Goldstein PA.  2011.  PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.. J Neurosci. 31(28):10412-23.
Jia F, Goldstein PA, Harrison NL.  2009.  The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.. J Pharmacol Exp Ther. 328(3):1000-6.
Naguib M, Gottumukkala V, Goldstein PA.  2007.  Melatonin and anesthesia: a clinical perspective.. J Pineal Res. 42(1):12-21.
Ying S-W, Werner DF, Homanics GE, Harrison NL, Goldstein PA.  2009.  Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.. Neuropharmacology. 56(2):438-47.
Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL.  2008.  Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.. J Pharmacol Exp Ther. 324(3):1127-35.
Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.  2005.  Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.. J Pharmacol Exp Ther. 315(2):517-25.
Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying S-W, Goldstein PA et al..  2015.  Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.. Anesthesiology. 122(5):1047-59.
Goldstein PA.  2015.  HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.. Anesth Analg. 121(3):594-6.
Tibbs GR, Rowley TJ, R Sanford L, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD.  2013.  HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.. J Pharmacol Exp Ther. 345(3):363-73.
Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA.  2005.  An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.. J Neurophysiol. 94(6):4491-501.
Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL.  2005.  Emerging molecular mechanisms of general anesthetic action.. Trends Pharmacol Sci. 26(10):503-10.
Ying S-W, Jia F, Abbas SY, Hofmann F, Ludwig A, Goldstein PA.  2007.  Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.. J Neurosci. 27(32):8719-32.
Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR.  2014.  cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.. PLoS One. 9(7):e101236.