Department of Anesthesiology

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Zhang Y, Sharma M, Eger EI, Laster MJ, Hemmings HC, R Harris A. 2008. Intrathecal veratridine administration increases minimum alveolar concentration in rats.. Anesth Analg. 107(3):875-8.

Ouyang W, Wang G, Hemmings HC. 2003. Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals.. Mol Pharmacol. 64(2):373-81.

Torturo CL, Zhou Z-Y, Ryan TA, Hemmings HC. 2019. Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons.. eNeuro. 6(1)

Ouyang W, Jih T-Y, Zhang T-T, Correa AM, Hemmings HC. 2007. Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.. J Pharmacol Exp Ther. 322(3):1076-83.

Baumgart JP, Zhou Z-Y, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC. 2015. Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.. Proc Natl Acad Sci U S A. 112(38):11959-64.

Herold KF, Nau C, Ouyang W, Hemmings HC. 2009. Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.. Anesthesiology. 111(3):591-9.

Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC. 2017. Isoflurane modulates activation and inactivation gating of the prokaryotic Na(+) channel NaChBac.. J Gen Physiol. 149(6):623-638.

Zhao W, Zhang M, Liu J, Liang P, Wang R, Hemmings HC, Zhou C. 2019. Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.. Anesthesiology. 131(1):94-104.

Platholi J, Herold KF, Hemmings HC, Halpain S. 2014. Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.. PLoS One. 9(7):e102978.

Ouyang W, Hemmings HC. 2007. Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.

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Hemmings HC. 2004. Neuroprotection by Na+ channel blockade.. J Neurosurg Anesthesiol. 16(1):100-1.

Perouansky M, Hemmings HC. 2009. Neurotoxicity of general anesthetics: cause for concern? Anesthesiology. 111(6):1365-71.

Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM. 2008. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 107(3):832-48.

Hemmings HC. 2007. Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.

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Hotte M, Thuault S, Dineley KT, Hemmings HC, Nairn AC, Jay TM. 2007. Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.. Synapse. 61(1):24-8.

Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC, Nishi A, Greengard P, Nairn AC. 2005. Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).. Proc Natl Acad Sci U S A. 102(9):3489-94.

Ingólfsson HI, Thakur P, Herold KF, E Hobart A, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K et al.. 2014. Phytochemicals perturb membranes and promiscuously alter protein function.. ACS Chem Biol. 9(8):1788-98.

Hemmings HC, Greengard P. 2010. Positively active: how local anesthetics work.. Anesthesiology. 113(1):250-2.

Zhang TT, Platholi J, Heerdt PM, Hemmings HC, Tung HYL. 2008. Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.. Metab Brain Dis. 23(1):95-104.

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Morrow PW, Tung HYLim, Hemmings HC. 2004. Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells.. Biochem Biophys Res Commun. 323(2):645-51.

Westphalen RI, Yu J, Krivitski M, Jih T-Y, Hemmings HC. 2010. Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.. J Neurochem. 113(6):1611-20.

Westphalen RI, Kwak N-B, Daniels K, Hemmings HC. 2011. Regional differences in the effects of isoflurane on neurotransmitter release.. Neuropharmacology. 61(4):699-706.

Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC. 2014. Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.. J Biol Chem. 289(34):23893-900.

Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC, Nairn AC, Bibb JA. 2007. Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.. J Biol Chem. 282(22):16511-20.

Riegelhaupt PM, Hemmings HC, Goldstein PA. 2016. Relevance of Clinical Relevance.. Anesthesiology. 125(4):821-2.