Department of Anesthesiology
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Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC.  2014.  Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.. J Biol Chem. 289(34):23893-900.
Westphalen RI, Kwak N-B, Daniels K, Hemmings HC.  2011.  Regional differences in the effects of isoflurane on neurotransmitter release.. Neuropharmacology. 61(4):699-706.
Westphalen RI, Yu J, Krivitski M, Jih T-Y, Hemmings HC.  2010.  Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.. J Neurochem. 113(6):1611-20.
Morrow PW, Tung HYLim, Hemmings HC.  2004.  Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells.. Biochem Biophys Res Commun. 323(2):645-51.
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Zhang TT, Platholi J, Heerdt PM, Hemmings HC, Tung HYL.  2008.  Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.. Metab Brain Dis. 23(1):95-104.
Atasoy-Rodriguez IL, Johnson KW, Patel K, Arain H, Zaidi S, Herold KF, Milner TA, Hemmings HC, Platholi J.  2026.  Presynaptic NMDA receptors on mouse mossy fiber terminals mediate rapid BDNF release by ketamine and hydroxynorketamine.. bioRxiv.
Hemmings HC, Greengard P.  2010.  Positively active: how local anesthetics work.. Anesthesiology. 113(1):250-2.
Ingólfsson HI, Thakur P, Herold KF, E Hobart A, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K et al..  2014.  Phytochemicals perturb membranes and promiscuously alter protein function.. ACS Chem Biol. 9(8):1788-98.
Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC, Nishi A, Greengard P, Nairn AC.  2005.  Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).. Proc Natl Acad Sci U S A. 102(9):3489-94.
Hotte M, Thuault S, Dineley KT, Hemmings HC, Nairn AC, Jay TM.  2007.  Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.. Synapse. 61(1):24-8.
Orser BA, Brenna CTA, Hemmings HC, Wang D-S.  2026.  A perfect storm: consequences of excess inhibitory neurotransmission after anaesthesia and surgery.. Br J Anaesth.
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Eastman RT, Rusinova R, Herold KF, Huang X-P, Dranchak P, Voss TC, Rana S, Shrimp JH, White AD, Hemmings HC et al..  2023.  Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity.. bioRxiv.
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM.  2008.  Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 107(3):832-48.
Perouansky M, Hemmings HC.  2009.  Neurotoxicity of general anesthetics: cause for concern? Anesthesiology. 111(6):1365-71.
Hemmings HC.  2004.  Neuroprotection by Na+ channel blockade.. J Neurosurg Anesthesiol. 16(1):100-1.
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Platholi J, Hemmings HC.  2021.  Modulation of dendritic spines by protein phosphatase-1.. Adv Pharmacol. 90:117-144.
Eastman RT, Rusinova R, Herold KF, Huang X-P, Voss T, White AD, Hemmings HC, Andersen OS, Dahlin JL.  2025.  Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability.. J Med Chem.
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Ouyang W, Hemmings HC.  2007.  Isoform-selective effects of isoflurane on voltage-gated Na+ channels.. Anesthesiology. 107(1):91-8.
Zhao W, Zhao S, Zhu T, Ou M, Zhang D, Sun H, Liu J, Chen X, Hemmings HC, Zhou C.  2021.  Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice.. Anesthesiology.
Platholi J, Herold KF, Hemmings HC, Halpain S.  2014.  Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.. PLoS One. 9(7):e102978.
Zhao W, Zhang M, Liu J, Liang P, Wang R, Hemmings HC, Zhou C.  2019.  Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.. Anesthesiology. 131(1):94-104.
Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC.  2017.  Isoflurane modulates activation and inactivation gating of the prokaryotic Na(+) channel NaChBac.. J Gen Physiol. 149(6):623-638.
Herold KF, Nau C, Ouyang W, Hemmings HC.  2009.  Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.. Anesthesiology. 111(3):591-9.
Baumgart JP, Zhou Z-Y, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC.  2015.  Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.. Proc Natl Acad Sci U S A. 112(38):11959-64.