Department of Anesthesiology
Author [ Title(Desc)] Type Year
Filters: Keyword is Binding Sites  [Clear All Filters]
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B
Picollo A, Malvezzi M, Houtman JCD, Accardi A.  2009.  Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.. Nat Struct Mol Biol. 16(12):1294-301.
C
Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E.  2006.  Channel or transporter? The CLC saga continues. Exp Physiol. 91(1):149-52.
Accardi A, Picollo A.  2010.  CLC channels and transporters: proteins with borderline personalities.. Biochim Biophys Acta. 1798(8):1457-64.
Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.  2003.  Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. Proc Natl Acad Sci U S A. 100(22):12607-12.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
I
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, D Camerino C, Pusch M.  2010.  Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.. Br J Pharmacol. 160(7):1652-61.
M
Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM.  2009.  Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
Naguib M, Gottumukkala V, Goldstein PA.  2007.  Melatonin and anesthesia: a clinical perspective.. J Pineal Res. 42(1):12-21.
Picollo A, Liantonio A, Didonna MPaola, Elia L, Camerino DConte, Pusch M.  2004.  Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.. EMBO Rep. 5(6):584-9.
N
Hemmings HC.  2007.  Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.. Anesthesiology. 107(5):694-6.
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.
O
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Greengard P, Czernik AJ.  2001.  Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.. J Neurosci. 21(20):7944-53.
P
Porotto M, Fornabaio M, Greengard O, Murrell MT, Kellogg GE, Moscona A.  2006.  Paramyxovirus receptor-binding molecules: engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site.. J Virol. 80(3):1204-13.
Picollo A, Malvezzi M, Accardi A.  2010.  Proton block of the CLC-5 Cl-/H+ exchanger.. J Gen Physiol. 135(6):653-9.
R
Gradogna A, Babini E, Picollo A, Pusch M.  2010.  A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.. J Gen Physiol. 136(3):311-23.
S
Liantonio A, De Luca A, Pierno S, Didonna MPaola, Loiodice F, Fracchiolla G, Tortorella P, Antonio L, Bonerba E, Traverso S et al..  2003.  Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.. Br J Pharmacol. 139(7):1255-64.
McCoy JG, Bitto E, Bingman CA, Wesenberg GE, Bannen RM, Kondrashov DA, Phillips GN.  2007.  Structure and dynamics of UDP-glucose pyrophosphorylase from Arabidopsis thaliana with bound UDP-glucose and UTP.. J Mol Biol. 366(3):830-41.
McCoy JG, Arabshahi A, Bitto E, Bingman CA, Ruzicka FJ, Frey PA, Phillips GN.  2006.  Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana.. Biochemistry. 45(10):3154-62.
McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN.  2006.  Structure and mechanism of mouse cysteine dioxygenase.. Proc Natl Acad Sci U S A. 103(9):3084-9.
Bitto E, Bingman CA, McCoy JG, Allard STM, Wesenberg GE, Phillips GN.  2005.  The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 61(Pt 12):1655-61.
McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN.  2006.  Structure of an ETHE1-like protein from Arabidopsis thaliana.. Acta Crystallogr D Biol Crystallogr. 62(Pt 9):964-70.
Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN.  2006.  Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.. J Biol Chem. 281(29):20521-9.
Zhu J, Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D et al..  2012.  Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.. Sci Transl Med. 4(125):125ra32.