Department of Anesthesiology
Author Title Type [ Year(Asc)]
Filters: Author is Nimigean, Crina M  [Clear All Filters]
2024
Thon O, Wang Z, Schmidpeter PAM, Nimigean CM.  2024.  PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.. Nat Commun. 15(1):8230.
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, H Larsson P et al..  2024.  Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.. Nature.
2023
Fan C, Flood E, Sukomon N, Agarwal S, Allen TW, Nimigean CM.  2023.  Calcium-gated potassium channel blockade via membrane-facing fenestrations.. Nat Chem Biol.
Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S.  2023.  Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel.. Nat Struct Mol Biol. 30(4):512-520.
Schmidpeter PAM, Petroff JT, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM.  2023.  Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.. Nat Commun. 14(1):1077.
Lansky S, Betancourt JMichael, Zhang J, Jiang Y, Kim ED, Paknejad N, Nimigean CM, Yuan P, Scheuring S.  2023.  A pentameric TRPV3 channel with a dilated pore.. Nature. 621(7977):206-214.
2022
Nimigean CM.  2022.  35 years of channelling potassium ions.. Nature. 608(7924):670-672.
Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM.  2022.  Anionic lipids unlock the gates of select ion channels in the pacemaker family.. Nat Struct Mol Biol. 29(11):1092-1100.
Sukomon N, Fan C, Nimigean CM.  2022.  Ball-and-Chain Inactivation in Potassium Channels.. Annu Rev Biophys.
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM.  2022.  Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.. Nat Commun. 13(1):6919.
2021
Schmidpeter PAM, Nimigean CM.  2021.  Correlating ion channel structure and function.. Methods Enzymol. 652:3-30.
2020
Fan C, Sukomon N, Flood E, Rheinberger J, Allen TW, Nimigean CM.  2020.  Ball-and-chain inactivation in a calcium-gated potassium channel.. Nature. 580(7802):288-293.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
Nimigean CM.  2020.  Polyamine block of MthK potassium channels.. J Gen Physiol. 152(7)
2019
Xu Y, Zhang D, Rogawski R, Nimigean CM, McDermott AE.  2019.  Identifying coupled clusters of allostery participants through chemical shift perturbations.. Proc Natl Acad Sci U S A. 116(6):2078-2085.
2018
Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.  2018.  High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.. Structure. 26(1):20-27.e3.
Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM.  2018.  Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.. J Gen Physiol.
Rheinberger J, Gao X, Schmidpeter PAm, Nimigean CM.  2018.  Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.. Elife. 7
Posson DJ, Rusinova R, Andersen OS, Nimigean CM.  2018.  Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.. Methods Mol Biol. 1684:223-235.
2017
Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J.  2017.  Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6
2016
Kim DM, Dikiy I, Upadhyay V, Posson DJ, Eliezer D, Nimigean CM.  2016.  Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.. J Gen Physiol. 148(2):119-32.
Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S.  2016.  Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.. Nat Commun. 7:12789.
Kim DM, Nimigean CM.  2016.  Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.. Cold Spring Harb Perspect Biol. 8(5)
2015
Posson DJ, Rusinova R, Andersen OS, Nimigean CM.  2015.  Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.. Nat Commun. 6:8342.
2014
McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Cartagena AJaramillo, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS et al..  2014.  A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.. J Biol Chem. 289(14):9535-46.