Department of Anesthesiology
Author Title [ Type(Desc)] Year
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Journal Article
Nimigean CM.  2022.  35 years of channelling potassium ions.. Nature. 608(7924):670-672.
Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM.  2022.  Anionic lipids unlock the gates of select ion channels in the pacemaker family.. Nat Struct Mol Biol. 29(11):1092-1100.
Fan C, Sukomon N, Flood E, Rheinberger J, Allen TW, Nimigean CM.  2020.  Ball-and-chain inactivation in a calcium-gated potassium channel.. Nature. 580(7802):288-293.
Sukomon N, Fan C, Nimigean CM.  2022.  Ball-and-Chain Inactivation in Potassium Channels.. Annu Rev Biophys.
Posson DJ, Rusinova R, Andersen OS, Nimigean CM.  2015.  Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.. Nat Commun. 6:8342.
Zadek B, Nimigean CM.  2006.  Calcium-dependent gating of MthK, a prokaryotic potassium channel.. J Gen Physiol. 127(6):673-85.
Fan C, Flood E, Sukomon N, Agarwal S, Allen TW, Nimigean CM.  2023.  Calcium-gated potassium channel blockade via membrane-facing fenestrations.. Nat Chem Biol.
Kim DM, Dikiy I, Upadhyay V, Posson DJ, Eliezer D, Nimigean CM.  2016.  Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.. J Gen Physiol. 148(2):119-32.
Schmidpeter PAM, Nimigean CM.  2021.  Correlating ion channel structure and function.. Methods Enzymol. 652:3-30.
Nimigean CM, Shane T, Miller C.  2004.  A cyclic nucleotide modulated prokaryotic K+ channel.. J Gen Physiol. 124(3):203-10.
Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S.  2023.  Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel.. Nat Struct Mol Biol. 30(4):512-520.
Nimigean CM, Chappie JS, Miller C.  2003.  Electrostatic tuning of ion conductance in potassium channels.. Biochemistry. 42(31):9263-8.
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM.  2022.  Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.. Nat Commun. 13(1):6919.
Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg H.  2018.  High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.. Structure. 26(1):20-27.e3.
Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J.  2017.  Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6
Xu Y, Zhang D, Rogawski R, Nimigean CM, McDermott AE.  2019.  Identifying coupled clusters of allostery participants through chemical shift perturbations.. Proc Natl Acad Sci U S A. 116(6):2078-2085.
McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Cartagena AJaramillo, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS et al..  2014.  A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.. J Biol Chem. 289(14):9535-46.
Nimigean CM, Pagel MD.  2007.  Ligand binding and activation in a prokaryotic cyclic nucleotide-modulated channel.. J Mol Biol. 371(5):1325-37.
Schmidpeter PAM, Gao X, Uphadyay V, Rheinberger J, Nimigean CM.  2018.  Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.. J Gen Physiol.
Rheinberger J, Gao X, Schmidpeter PAm, Nimigean CM.  2018.  Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.. Elife. 7
Kowal J, Chami M, Baumgartner P, Arheit M, Chiu P-L, Rangl M, Scheuring S, Schröder GF, Nimigean CM, Stahlberg H.  2014.  Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.. Nat Commun. 5:3106.
Cheng WWL, McCoy JG, Thompson AN, Nichols CG, Nimigean CM.  2011.  Mechanism for selectivity-inactivation coupling in KcsA potassium channels.. Proc Natl Acad Sci U S A. 108(13):5272-7.
Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM.  2009.  Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM.  2020.  Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9
Schmidpeter PAM, Petroff JT, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM.  2023.  Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.. Nat Commun. 14(1):1077.