Department of Anesthesiology
Author [ Title(Desc)] Type Year
Filters: Author is Accardi, Alessio  [Clear All Filters]
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A
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HDidar, Falzone ME, Huysmans G, Robertson JL et al..  2024.  Author Correction: Structural basis of pH-dependent activation in a CLC transporter.. Nat Struct Mol Biol.
B
Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A.  2022.  Backbone amides are determinants of Cl- selectivity in CLC ion channels.. Nat Commun. 13(1):7508.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.  2025.  Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. Nat Commun. 16(1):1769.
Picollo A, Malvezzi M, Houtman JCD, Accardi A.  2009.  Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.. Nat Struct Mol Biol. 16(12):1294-301.
Iyer R, Iverson TM, Accardi A, Miller C.  2002.  A biological role for prokaryotic ClC chloride channels.. Nature. 419(6908):715-8.
C
Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A.  2013.  Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.. Nat Commun. 4:2367.
Accardi A.  2015.  CELL SIGNALING. Lipids link ion channels and cancer.. Science. 349(6250):789-90.
Accardi A, Picollo A.  2010.  CLC channels and transporters: proteins with borderline personalities.. Biochim Biophys Acta. 1798(8):1457-64.
Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.  2003.  Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. Proc Natl Acad Sci U S A. 100(22):12607-12.
Accardi A, Pusch M.  2003.  Conformational changes in the pore of CLC-0.. J Gen Physiol. 122(3):277-93.
Basilio D, Noack K, Picollo A, Accardi A.  2014.  Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.. Nat Struct Mol Biol. 21(5):456-63.
Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.  2003.  Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.. Neuron. 38(1):47-59.
D
Khelashvili G, Falzone ME, Cheng X, Lee B-C, Accardi A, Weinstein H.  2019.  Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16.. Nat Commun. 10(1):4972.
Hara Y, Balci-Hayta B, Yoshida-Moriguchi T, Kanagawa M, de Bernabé DBeltrán-V, Gündeşli H, Willer T, Satz JS, Crawford RW, Burden SJ et al..  2011.  A dystroglycan mutation associated with limb-girdle muscular dystrophy.. N Engl J Med. 364(10):939-46.
G
Lee B-C, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A.  2018.  Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.. Nat Commun. 9(1):3251.
I
Feng Z, Di Zanni E, Alvarenga O, Chakraborty S, Rychlik N, Accardi A.  2024.  In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins. Cell Calcium. 121:102896.
Jayaram H, Accardi A, Wu F, Williams C, Miller C.  2008.  Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.. Proc Natl Acad Sci U S A. 105(32):11194-9.
Accardi A, Kolmakova-Partensky L, Williams C, Miller C.  2004.  Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.. J Gen Physiol. 123(2):109-19.
K
Falzone ME, Malvezzi M, Lee B-C, Accardi A.  2018.  Known structures and unknown mechanisms of TMEM16 scramblases and channels.. J Gen Physiol.
M
Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DConte, Conti F.  2002.  Mechanisms of block of muscle type CLC chloride channels (Review).. Mol Membr Biol. 19(4):285-92.
Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.  2020.  Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.. J Comput Chem. 41(6):538-551.
Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A et al..  2002.  Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.. Mol Pharmacol. 62(2):265-71.
N
Lee B-C, Menon AK, Accardi A.  2016.  The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.
Corral-Rodríguez MÁngeles, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AIbáñez, Blanco FJ, Encinar JAntonio, Spiwok V et al..  2014.  Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.. Biochem J. 464(1):23-34.
O
Malvezzi M, Andra KK, Pandey K, Lee B-C, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.  2018.  Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. Proc Natl Acad Sci U S A. 115(30):E7033-E7042.