Publications | Department of Anesthesiology

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Kim DM, Nimigean CM. 2016. Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.. Cold Spring Harb Perspect Biol. 8(5)

Posson DJ, McCoy JG, Nimigean CM. 2013. The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.. Nat Struct Mol Biol. 20(2):159-66.

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Chiu P-L, Pagel MD, Evans J, Chou H-T, Zeng X, Gipson B, Stahlberg H, Nimigean CM. 2007. The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution.. Structure. 15(9):1053-64.

McCoy JG, Nimigean CM. 2012. Structural correlates of selectivity and inactivation in potassium channels.. Biochim Biophys Acta. 1818(2):272-85.

Tanabe M, Nimigean CM, Iverson TM. 2010. Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.. Proc Natl Acad Sci U S A. 107(15):6811-6.

Posson DJ, Rusinova R, Andersen OS, Nimigean CM. 2018. Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.. Methods Mol Biol. 1684:223-235.

Qian X, Nimigean CM, Niu X, Moss BL, Magleby KL. 2002. Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels.. J Gen Physiol. 120(6):829-43.

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Rusinova R, Kim DM, Nimigean CM, Andersen OS. 2014. Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay.. Biophys J. 106(5):1070-8.

Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S. 2016. Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.. Nat Commun. 7:12789.

Nimigean CM. 2006. A radioactive uptake assay to measure ion transport across ion channel-containing liposomes.. Nat Protoc. 1(3):1207-12.

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Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, H Larsson P et al.. 2024. Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.. Nature.

Nimigean CM. 2020. Polyamine block of MthK potassium channels.. J Gen Physiol. 152(7)

Thon O, Wang Z, Schmidpeter PAM, Nimigean CM. 2024. PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.. Nat Commun. 15(1):8230.

Park T, Nimigean CM. 2025. PIP2 Binding at Allosteric Site Blocks Activation in Human Rod CNG Channels.. bioRxiv.

Lansky S, Betancourt JMichael, Zhang J, Jiang Y, Kim ED, Paknejad N, Nimigean CM, Yuan P, Scheuring S. 2023. A pentameric TRPV3 channel with a dilated pore.. Nature. 621(7977):206-214.

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Nimigean CM, Allen TW. 2011. Origins of ion selectivity in potassium channels from the perspective of channel block.. J Gen Physiol. 137(5):405-13.

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Banerjee S, Nimigean CM. 2011. Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers.. J Gen Physiol. 137(2):217-23.

Nimigean CM, Miller C. 2002. Na+ block and permeation in a K+ channel of known structure.. J Gen Physiol. 120(3):323-35.

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Thompson AN, Posson DJ, Parsa PV, Nimigean CM. 2008. Molecular mechanism of pH sensing in KcsA potassium channels.. Proc Natl Acad Sci U S A. 105(19):6900-5.

Posson DJ, Thompson AN, McCoy JG, Nimigean CM. 2013. Molecular interactions involved in proton-dependent gating in KcsA potassium channels.. J Gen Physiol. 142(6):613-24.

Schmidpeter PAM, Petroff JT, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM. 2023. Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.. Nat Commun. 14(1):1077.

Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM. 2020. Mechanistic insights into volatile anesthetic modulation of K2P channels.. Elife. 9

Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM. 2009. Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.. Nat Struct Mol Biol. 16(12):1317-24.

Li C-C, Nimigean CM. 2026. Mechanism of lipid-dependent cold sensitivity in a model ion channel.. Nat Commun.

Cheng WWL, McCoy JG, Thompson AN, Nichols CG, Nimigean CM. 2011. Mechanism for selectivity-inactivation coupling in KcsA potassium channels.. Proc Natl Acad Sci U S A. 108(13):5272-7.