The Basic Science Research Division is dedicated to the study of anesthetic mechanisms and molecular pharmacology, neurophysiology, biophysics, biochemistry, and cardiac physiology. The Department of Anesthesiology operates three major lab spaces with five principal investigators. A further three principal investigators work out of collaborative ventures in laboratories at Rockefeller University and Memorial Sloan-Kettering Cancer Center.
Current active investigations include studies on the synaptic effects of anesthetic agents and mechanisms of neuronal signal transduction; mechanisms of gating, selectivity, and modulation of potassium channels; the role of thalamic HCN1 channels in arousal; the structural and functional underpinnings of genetic disease associated with ion channels and transporters; systems-level analysis of thalamocortical activity in consciousness; computer network modeling of anesthetic effects on hippocampal connectivity; systems-levels effects of anesthetics on emotional and memory systems; and cardiopulmonary physiology.
Basic Science research conducted by the Department of Anesthesiology features in several of the world’s most prominent scientific and specialty journals, including Nature, Proceedings of the National Academy of Sciences, Journal of Neuroscience, Natural Structure & Molecular Biology, Neuron, EMBO Journal, Anesthesiology, PLOS ONE, and the Journal of Neurophysiology. The laboratories have trained a significant number of postdoctoral fellows who have gone on to successful research careers. Research opportunities exist for students of all levels.