Department of Anesthesiology

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Investigator Labs

Part of the CV Starr Laboratory for Molecular Pharmacology

Work in the Accardi lab is aimed at uncovering the molecular and structural underpinnings regulating the movement of charged ions across cellular membranes. This process results in the electrical currents underlying scores of fundamental physiological processes such as the neuronal action potential, muscle contraction, insulin secretion and signal transduction. In the lab, we use a combination of techniques to study this phenomenon, ranging from X-ray crystallography, to single channel and macroscopic current electrophysiology, calorimetry, reconstitution into synthetic lipid bilayers and other biochemical assays.

Members

Alessio Accardi

Alessio Accardi, PhD — Principal Investigator
Associate Professor of Physiology and Biophysics in Anesthesiology
Associate Professor of Physiology and Biophysics
Associate Professor of Biochemistry

Alessandra Picollo, Ph.D.
Postdoctoral Associate

Mattia Malvezzi, Ph.D.
Postdoctoral Associate

Byoungcheol Lee, Ph.D.
Postdoctoral Associate

Karolyn Le
Laboratory Technician

Latrice Goss
Research Administrative Specialist
phone: 212-746-5325
fax: 212-746-4879

Part of the CV Starr Laboratory for Molecular Pharmacology

The overall focus of the lab is to better define the mechanisms by which a diverse group of pharmacological agents produce anesthesia. A potentially important region within the central nervous system (CNS) for contributing to the anesthetized state is the thalamus. This raises a number of basic questions, such as: What are the effects of different anesthetics on synaptic transmission in the thalamus? Do these drugs have unique effects in specific thalamic regions as a function of differences in receptor expression? GABA release is controlled by multiple mechanisms, including a variety of ion channels; is the function of those channels altered in the presence of anesthetics? The lab uses electrophysiological, immunohistochemical, and molecular biological techniques to address those issues.

Members

Peter Goldstein

Peter Goldstein, MD — Principal Investigator
Professor of Anesthesiology
Associate Professor of Ethics

Gareth Tibbs, PhD
Research Consultant

Latrice Goss 
Research Administrative Specialist
phone: 212-746-5325
fax: 212-746-4879

The Laboratory of Molecular Anesthesiology

In the Hemmings laboratory, the effects of general anesthetics on neurotransmitter release (e.g., glutamate, GABA, dopamine, norepinephrine, neuropeptides) and on their interactions between specific presynaptic proteins involved in the control of neurotransmitter release (ion channels, SNAREs) are being studied at the behavioral, network, cellular and molecular levels in animal models, cultured cells and neurons, brain slices, isolated nerve terminals and using purified recombinant proteins. Techniques include biochemical, imaging, and electro-physiological approaches.

Members

Hugh Hemmings

Hugh Hemmings Jr., MD, PhD — Principal Investigator
Professor of Anesthesiology
Professor of Pharmacology
Chair of Anesthesiology

Karl Herold, M.D., Ph.D.
Research Associate

Zhenyu Zhou, M.D., Ph.D.
Research Associate

Rheanna Sand, Ph.D.
Postdoctoral Associate

Masato Hara, M.D., Ph.D.
Postdoctoral Associate

Jimcy Platholi, Ph.D.
Assistant Professor of Pharmacology Research in Anesthesiology

Kerry Purtell, B.S.
Graduate Student

Christina Bonvicino, B.S.
Graduate Student

Anna Adamo
Research Laboratory Coordinator

Latrice Goss
Research Administrative Specialist
phone: 212-746-2744
fax: 212-746-8316

Visit the Hemmings Lab website:

Hemmings Lab Webpage

Part of the CV Starr Laboratory for Molecular Pharmacology

Research in the Nimigean Laboratory is geared toward understanding how ion channel protein structure and mechanism interrelate at the molecular level to allow channels to elaborate various biological properties. We use a combination of molecular, biochemical and electrophysiological approaches to evaluate in a complete fashion fundamental channel properties within the context of emerging structural data.

Members

Crina Nimigean

Crina Nimigean, PhD — Principal Investigator
Associate Professor of Physiology and Biophysics in Anesthesiology (with Tenure)
Associate Professor of Physiology and Biophysics
Associate Professor of Biochemistry

David Posson, Ph.D.
Postdoctoral Associate

Vikrant Uphadyay, Ph.D.
Postdoctoral Associate

Dorothy Kim, Ph.D.
Postdoctoral Associate

Alexis Jaramillo
Graduate Student

Karolyn LeLaboratory Technician

Latrice Goss
Research Administrative Specialist
phone: 212-746-5325
fax: 212-746-4879

Visit the Nimigean Lab Website:

Nimigean Lab Website

The Laboratory of Anesthetic Neuropsychopharmacology

The Pryor Lab studies the interaction between anesthetic drugs and the memory and emotional systems of the human brain. Because anesthetics have such a remarkable effect on human memory, careful study of the mechanisms of these drugs can provide critical insight into how human memory functions work. This research involves the use of functional magnetic resonance imaging, electroencephalography, and neurophysiology techniques.

Members

Kane Pryor, MD — Principal Investigator
Assistant Professor of Anesthesiology
Assistant Professor of Anesthesiology in Psychiatry
Director of Clinical Research

James Root, PhD
Experimental Neuropsychologist

Meghana Mehta, ME
Computer Programming Specialist

Contact Us

Dept. of Anesthesiology
NewYork-Presbyterian Hospital/Weill Cornell Medicine
525 East 68th Street, Box 124
New York, NY 10065
Fax: (212) 746-8563

Office of the Chair
Phone: (212) 746-2962
E-mail:  Marissa Matarazzo, mam7036@med.cornell.edu

Residency and Fellowship Education
Direct all inquiries to:
Phone: (212) 746-2941
E-mail: anes-programs@med.cornell.edu

Patient Billing Inquiries
Phone: (855) 880-0343